dc.contributor.author |
Kumar, Rohtash |
|
dc.contributor.author |
Avinash, Avinash |
|
dc.contributor.author |
Mehta, Ronak |
|
dc.contributor.author |
Appayee, Chandrakumar |
|
dc.coverage.spatial |
United Kingdom |
|
dc.date.accessioned |
2025-05-01T15:06:28Z |
|
dc.date.available |
2025-05-01T15:06:28Z |
|
dc.date.issued |
2025-04 |
|
dc.identifier.citation |
Kumar, Rohtash; Avinash, Avinash; Mehta, Ronak and Appayee, Chandrakumar, "Nonsilyl bicyclic secondary amine catalyzed Michael addition of nitromethane to β,β-disubstituted α,β-unsaturated aldehydes" Organic & Biomolecular Chemistry, DOI: 10.1039/D5OB00277J, Apr. 2025. |
|
dc.identifier.issn |
1477-0520 |
|
dc.identifier.issn |
1477-0539 |
|
dc.identifier.uri |
https://doi.org/10.1039/D5OB00277J |
|
dc.identifier.uri |
https://repository.iitgn.ac.in/handle/123456789/11365 |
|
dc.description.abstract |
The asymmetric Michael addition of nitroalkanes to β,β-disubstituted α,β-unsaturated aldehydes is a useful method for the construction of all-carbon quaternary stereocenters. Nonsilyl bicyclic secondary amine organocatalysts were employed in reactions involving a wide range of β,β-disubstituted α,β-unsaturated aldehydes with nitroalkanes to achieve products with all-carbon quaternary stereocenters in up to 69% yield and 95% ee. The scalability of this methodology was demonstrated at the 5.1 mmol scale. The synthetic utility of this methodology is showcased through the concise asymmetric synthesis of methsuximide, an anticonvulsant drug. |
|
dc.description.statementofresponsibility |
by Rohtash Kumar, Avinash Avinash, Ronak Mehta and Chandrakumar Appayee |
|
dc.language.iso |
en_US |
|
dc.publisher |
Royal Society of Chemistry |
|
dc.title |
Nonsilyl bicyclic secondary amine catalyzed Michael addition of nitromethane to β,β-disubstituted α,β-unsaturated aldehydes |
|
dc.type |
Article |
|
dc.relation.journal |
Organic & Biomolecular Chemistry |
|