Gefitinib (GEF) is an ATP-competitive inhibitor used in the treatment of advanced non-small cell lung cancer. However, the pharmaceutical efficacy of this drug is currently limited due to poor aqueous solubility (2.55 μg ...

Lipid droplets (LDs), owing to their involvement in various physiological processes and diseases such as fatty liver disease, diabetes, and cancer, have attracted considerable attention. Live cell imaging of lipid droplets ...

?-Secretase activating protein (GSAP) is known to play an important role in the ?-amyloid pathway. It acts as a modulator and accentuates the truncation of the amyloid precursor protein C-99 fragment through the ?-secretase ...

A new class of polystyrene-supported aminocatalysts with a triazole linker from diphenyl prolinol is achieved. Their catalytic activity is tested in the asymmetric α-amination of aldehydes. The substrate scope of this ...

In recent years, mitochondrion (powerhouse of the cells) gained lots of interest as one of the unorthodox targets for futuristic cancer therapy. As a result, novel small molecules were developed to damage and image ...

The alterations in the expression patterns of protein kinases often implicate human cancer initiation and progression. Human tousled-like kinases (TLKs), both TLK1/1B and TLK2, are evolutionary kinases found in cell signaling ...

A platform of recent interest and large application potential is one in which the light emitters are directly integrated with an optical metasurface. Plasmonic metals and high-refractive-index, dielectric Mie metasurfaces ...

The strategic incorporation of the neurotransmitter dopamine around a cobaloxime core resulted in excellent electrocatalytic (rate 8400 s-1) and photocatalytic H2 production under neutral aqueous conditions. The influence ...

Electrolysis of water is a sustainable route to produce clean hydrogen. Full water-splitting requires a high applied potential, in part because of the pH-dependency of the H2 and O2 evolution reactions. The HER and OER are ...

Alcoholic liver disease (ALD) alters gut microbiota and tight junctions, causing bacterial components to enter the portal vein and induce oxidative stress-induced inflammation in the liver. Only corticosteroids and liver ...