| dc.contributor.author |
Maurya, Vidyasagar |
|
| dc.contributor.author |
Appayee, Chandrakumar |
|
| dc.date.accessioned |
2019-12-30T10:09:23Z |
|
| dc.date.available |
2019-12-30T10:09:23Z |
|
| dc.date.issued |
2019-12 |
|
| dc.identifier.citation |
Maurya, Vidyasagar and Appayee, Chandrakumar, "Enantioselective total synthesis of potent 9?-11-hydroxyhexahydrocannabinol", The Journal of Organic Chemistry, DOI: 10.1021/acs.joc.9b02962, Dec. 2019. |
en_US |
| dc.identifier.issn |
0022-3263 |
|
| dc.identifier.issn |
1520-6904 |
|
| dc.identifier.uri |
https://doi.org/10.1021/acs.joc.9b02962 |
|
| dc.identifier.uri |
https://repository.iitgn.ac.in/handle/123456789/5046 |
|
| dc.description.abstract |
The first total synthesis of potent cannabinoid, 9?-11-hydroxyhexahydrocannabinol is achieved through proline catalyzed inverse-electron-demand Diels�Alder reaction. Using this asymmetric catalysis, the cyclohexane ring is constructed with two chiral centers as a single diastereomer with 97% ee. The creation of the third chiral center and benzopyran ring is demonstrated with the elegant synthetic strategies. This mild and efficient synthetic methodology provides a new route for the asymmetric synthesis of the other potent hexahy-drocannabinols. |
|
| dc.description.statementofresponsibility |
by Vidyasagar Maurya and Chandrakumar Appayee |
|
| dc.language.iso |
en_US |
en_US |
| dc.publisher |
American Chemical Society |
en_US |
| dc.title |
Enantioselective total synthesis of potent 9?-11-hydroxyhexahydrocannabinol |
en_US |
| dc.type |
Article |
en_US |
| dc.relation.journal |
The Journal of Organic Chemistry |
|