Nanoparticle-based drugs and formulations: current status and emerging applications

Abstract

In the foreseeable future, pharmaceuticals market, nanomedicine and healthcare system will largely depend on the drug nanoparticles formulation technology. Perceiving this, a significant amount of research works focusing on the fundamentals of nanocrystallization and performance enhancement are being reported each day around the world. The nanocrystallization strategies� industrial applications mainly depend on the ability of the technique to produce nanoparticles of active pharmaceutical ingredients (APIs) with controlled particle size, narrow size distribution, stability, reproducibility, high solid loading, scale-up feasibility, suitable for a range of APIs, and cost-effectiveness. There are plenty of reports witnessing performance improvements of nanodrugs. The harmony between the nanocrystallization strategies, performance of nanodrugs, scale-up producibility, and industrial challenges remain untold and un-summarized stories in the field of pharmaceutical nanotechnology. This review is devoted to comprehensively discussing the promising nanocrystallization strategies, fundamental concepts, and promising results of nanodrugs. We have also reviewed the progress towards commercialization and market based on nanodrugs, further challenges towards industrial application and future direction of pharmaceutical technologies and its impact on the future of the healthcare system.