• Role of receptor Tyrosine Kinase AXL in cancer 

  Kumar, Rahul; Tanwar, Pranay; Bhatia, Dhiraj; Solanki, Raghu (Springer, 2025-07)

  AXL is a receptor tyrosine kinase (RTK) that has emerged as a promising therapeutic target for cancer treatment. AXL plays a pivotal role in cancer progression by promoting tumor growth, migration, invasion, resistance to ...
• Thiazolyl Benzenesulfonamide derivative as a novel inhibitor of Thymidine Kinase: promising therapeutics against staphylococcus aureus 

  Hadiya, Rajesh K.; Ashraf, Anam; Wang, Yuanyuan; Khan, Faez Iqbal; Khan, Mohammad Ali; Renuka, L.; Ahmad, Shahbaz; Noor, Saba; Shah, Kaushik; Datta, Bhaskar; Hassan, Md. Imtaiyaz (Wiley, 2025-07)

  The emergence of multidrug-resistant Staphylococcus aureus necessitates novel antimicrobial strategies. This study reports the synthesis and evaluation of thiazolyl benzenesulfonamide-derived synthetic kinase inhibitors ...
• Alpha-tocopherol conjugated DNA tetrahedron with enhanced cellular uptake and selective cytotoxicity for cancer therapeutics 

  Chithra, P.; Vaswani, Payal; Bhatia, Dhiraj (Cold Spring Harbor Laboratory, 2025-05)

  One of the most fatal diseases in the world, cancer, lacks proper therapies that are toxic to cancer cells and specifically kill them. A newly emerging field, DNA nanotechnology facilitates the design of programmable, ...
• Nucleobase self-assembly: aggregation, morphological characterization, and toxicity analysis 

  Dave, Raj; Jaiswal, Ankita; Singh, Ankur; Naseer, Anam; Patel, Monisha; Nazir, Aamir; Bhatia, Dhiraj; Gour, Nidhi; Verma, Sandeep (Royal Society of Chemistry, 2025-06)

  This study expands the platform for amyloidogenic building blocks, such as nucleobases, and their self-assembly. Here, we examine the self-assembly profile of nucleobases such as guanine, cytosine, and thymine and determine ...
• Comparing PAS domain coupled intrinsic dynamics in bHLH PAS domain transcription factor complexes 

  Sudarsanam, Karthik; Srivastava, Ashutosh; Tiwari, Sandhya P. (Cold Spring Harbor Laboratory, 2025-05)

  The basic Helix-Loop-Helix–Per-Arnt-Sim (bHLH-PAS) transcription factors (TFs) are regulators of several critical cellular functions such as circadian rhythm, hypoxia response and neuronal development. These proteins contain ...
• Impact of chlorine substitution on supramolecular architecture and non-covalent interactions in Ethyl 2-amino-6-chloro-4-aryl-7-hydroxy-4H-benzo[4,5-e]pyran-3-carboxylate Isomers: a combined experimental, crystallographic, theoretical, and antioxidant study 

  Jebaraj, Paul Daniel; Purushothaman, Michael; Loganathan, Karuppiah; Percino, M. Judith; Thiruvenkatam, Vijay; Venkatesan, Perumal (Springer, 2025-07)

  Two positional isomers, ethyl 2-amino-6-chloro-4-(2-chlorophenyl)-7-hydroxy-4H-benzo-[4,5-e]pyran-3-carboxylate (1) and ethyl 2-amino-6-chloro-4-(3-chlorophenyl)-7-hydroxy-4H-benzo- [4,5-e] pyran-3-carboxylate (2) were ...
• Synthesis and in vitro assessment of Triazole-based compounds as potential inhibitors of herpes simplex virus type 1 

  Mishra, Neha U.; Sanap, Kiran K.; Sharma, Pritesh C.; Kudale, Tulsiram; Vanawe, Jyoti; Biswas, Abhijit; Bhatia, Dhiraj (Cold Spring Harbor Laboratory, 2025-05)

  A library of novel 1,2,4-triazole derivatives fused with a pyrazine moiety (5a–5t) was successfully synthesized and evaluated for their therapeutic potential against HSV-I virus and oxidative stress. These compounds were ...
• DNA cross-over motifs based, programmable supramolecular hydrogels for mechanoregulatory effects of cellular behaviour and cytoskeleton reorganization 

  Singh, Ankur; Bhatia, Dhiraj (Cold Spring Harbor Laboratory, 2025-05)

  The development of mechanically tunable DNA-based supramolecular hydrogels that recapitulate the dynamic mechanoelastic properties of native extracellular matrices (ECMs) is critical for advancing 3D tissue engineering. ...
• ROS regulation of stigma papillae growth and maturation in Arabidopsis thaliana 

  Sankaranarayanan, Subramanian; Venkatesan, Sowmiya Devi; Davis, Thomas C.; Kessler, Sharon A. (Cold Spring Harbor Laboratory, 2025-04)

  Highly specialized stigma papillae cells play a critical role in plant reproduction. Their main purpose is to catch and interact with pollen, to mediate compatibility responses, to regulate pollen germination, and to guide ...
• Chemically engineered multifunctional hydrogel for potential use in biomedical applications: a report on synthesis, physicochemical characterizations, and in vitro evaluation 

  Barani, Prasanna Kumari; Yadav, Indu; Dan, Aniruddha; Singh, Ankur; Bhatia, Dhiraj; Dhanka, Mukesh (Elsevier, 2025-10)

  Addressing the limitations of conventional polymeric hydrogels in eradicating bacterial infection and stimulating cell activity within a biological environment presents a significant challenge. However, chemically engineered ...
• Upcycling fruit waste: a sustainable route to nanoparticles synthesis and applications 

  Bhalerao, Satyam; Patil, Jugal; Bhatia, Dhiraj; Singh, Nihal (American Chemical Society, 2025-07)

  Fruits are a common part of a healthy human diet as they are rich in vitamins, minerals, antioxidants, dietary fibers, and flavor. However, the processing and subsequent consumption of fruits result in a significant amount ...
• Shear-induced structural changes drive amorphous aggregate formation of human insulin 

  Panda, Chinmaya; Kumar, Sachin; Gupta, Sharad; Pandey, Lalit M. (Wiley, 2025-06)

  The aggregation of protein-based biopharmaceutical formulations constitutes a major challenge in the pharmaceutical industry, where physicochemical stressors, viz., temperature, pH, shear, and high concentrations, ...
• Splice it right: the role of PRP21 in regulating seed germination responses to ABA 

  Gawande, Nilesh D. (Oxford University Press, 2025-06)
• 3D printed metamaterials: properties, fabrication, and drug delivery applications 

  Singh, Hemant; Tuffaha, Muath; Tripathi, Shivi; Öztürk, Ayça Bal; Dave, Harshil; Dhanka, Mukesh; Avci, Huseyin; Nanda, Himansu Sekhar; Hassan, Shabir (Elsevier, 2025-09)

  Drug delivery is a process to deliver the required amount of a drug to a target site within an appropriate timeframe, while minimizing possible side effects and maximizing efficiency. This is accomplished by drug delivery ...
• Welcome message from the technical program Chairs 

  Mercado-Shekhar, Karla P.; Panicker, Mahesh R. (Institute of Electrical and Electronics Engineers (IEEE), 2024-03-27)
• Assembly of serotonin on DNA tetrahedron for application in treating α-Synucleinopathy 

  Parmar, Bhagyesh; Prakash, Geethu; Kosara, Sanjay; Jain, Sweny; Vaswani, Payal; Bhatia, Dhiraj (Springer, 2025-06)

  This study presents a comprehensive protocol for assembling and applying tetrahedral DNA nanostructures (TDNs) as carriers for neurotransmitter delivery, explicitly targeting the treatment of α-synucleinopathies such as ...
• Putative G-Quadruplex structures in dysregulated long non-coding RNA of Ovarian Cancer and their binding interactions with human serum Albumin 

  Singh, Deepshikha; Shukla, Chinmayee; Datta, Bhaskar (American Chemical Society, 2025-06)

  Long noncoding RNAs (lncRNAs) influence the progression, metastasis, and drug resistance of various cancers including ovarian cancer (OC). Putative G-quadruplex (G4)-forming sequences that are abundant in cancer-dysregulated ...
• Zingerone nanoparticle and laponite-embedded natural gum based injectable hydrogel for fast track wound repair 

  Meena, Manisha; Yadav, Indu; Barani, Prasanna Kumari; Gajjar, Devanshi; Joshi, Aneri; Seshadri, Sriram; Dhanka, Mukesh (Elsevier, 2025-11)

  Currently, the treatment modalities for hard-to-heal deep skin wounds are limited by bacterial growth, excessive wound exudate, elevated reactive oxygen species (ROS), and extensive tissue damage. This study reports a ...
• ROS regulation of stigma papillae growth and maturation in Arabidopsis thaliana 

  Sankaranarayanan, Subramanian; Venkatesan, Sowmiya D.; Davis, Thomas C.; Kessler, Sharon A. (Springer, 2025-06)

  Highly specialized stigma papillae cells play a critical role in plant reproduction. Their main purpose is to catch and interact with pollen, to mediate compatibility responses, to regulate pollen germination, and to guide ...
• Injectable self-healing dynamic aldehyde-gellan gum-based hydrogel nanocomposite with enhanced antibacterial and antioxidant wound dressing to alleviate chronic skin wound 

  Dan, Aniruddha; Singh, Hemant; Shah, Tishira K.; Sheikh, Wajid Mohammad; Shafi, Majid; Laxmanan, Karthikeyan; Jan, Jasmeena; Hassan, Shabir; Bashir, Showkeen Muzamil; Dhanka, Mukesh (Elsevier, 2025-08)

  The difficult-to-heal wounds present a significant challenge for current treatment modalities due to factors such as impaired tissue microenvironments, disrupted inflammatory balance, impaired cellular proliferation, and ...

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