DNA nano-biomaterials based futuristic technologies for tissue engineering and regenerative therapeutics

Abstract

The ability to completely repair or regenerate injured tissues or organs and restore their functionality has long been a goal of humankind. The advancements in tissue engineering and regenerative medicine have made this conceivable. With the ability to precisely manipulate nanoscale architectures for designing biomaterials, DNA nanotechnology has emerged as a groundbreaking technique in tissue engineering and regenerative medicine. DNA-based nanostructures are well-suited for directing cellular interactions, delivering therapeutic drugs, and mimicking extracellular matrix components due to their exceptional biocompatibility, programmability, and molecular recognition capabilities. Recent developments have demonstrated that DNA nanodevices can be used to administer drugs and growth factors in a controlled manner, as well as to enhance cell adhesion, proliferation, and differentiation. Furthermore, their capacity to respond to biological stimuli enables dynamic and adaptable tissue regeneration techniques. This review highlights the latest advances in DNA nanotechnology for regenerative applications, its benefits over traditional biomaterials, and potential future pathways for clinical translation.