Journal Articles: Recent submissions

Now showing items 261-280 of 317

Tracing the GSAP-APP C-99 interaction site in the β-amyloid pathway leading to Alzheimer's disease

Angira, Deekshi; Chikhale, Rupesh; Mehta, Kapilkumar; Bryce, Richard A.; Thiruvenkatam, Vijay (American Chemical Society, 2019-07)

Gamma secretase activating protein (GSAP) present in β-amyloid pathway orchestrates the formation of β-amyloid plaques by γ-secretase activation and is an emerging therapeutic target for the treatment of Alzheimer’s disease. ...
Investigation of nanoparticle immobilized cellulase: nanoparticle identity, linker length and polyphenol hydrolysis

Kumar, Sanjay; Morya, Vinod; Gadhavi, Joshna; Vishnoi, Anjani; Singh, Jaskaran; Datta, Bhaskar (Elsevier, 2019-05)

Cellulase containing nanobiocatalysts have been useful as an extraction tool based on their ability to disrupt plant cell walls. In this work, we investigate the effect of nanoparticle composition and chemical linkage ...
Mapping the processivity determinants of the Kinesin-3 motor domain

Scarabelli, Guido; Soppina, Virupakshi; Yao, Xin-Qiu; Atherton, Joseph; Moores, Carolyn A.; Verhey, Kristen J.; Grant, Barry J. (Elsevier, 2016-02)

Kinesin superfamily members play important roles in many diverse cellular processes including cell motility, cell division, intracellular transport and regulation of the microtubule cytoskeleton. How the properties of the ...
Distinct DNA sequence preference for histone occupancy in primary and transformed cells

Datta, Subhamoy; Patel, Manthan; Patel, Divyesh; Singh, Umashankar (SAGE Journals, 2019-04)

Genome-wide occupancy of several histone modifications in various cell types has been studied using chromatin immunoprecipitation (ChIP) sequencing. Histone occupancy depends on DNA sequence features like inter-strand ...
Elucidating the role of key structural motifs in antifreeze glycoproteins

Pandey, Poonam; Mallajosyula, Sairam Swaroop (Royal Society of Chemistry, 2019)

Antifreeze glycoproteins (AFGPs) are distinctively riveting class of bio-macromolecules, which endows the survival of organisms inhabiting polar and subpolar regions. These proteins are supposed to hinder the microscopic ...
Effectual template banks for upcoming compact binary searches in Advanced-LIGO and Virgo data

Arpag, Goker; Norris, Stephen R.; Mousavi, S. Iman; Soppina, Virupakshi; Verhey, Kristen J.; Hancock, William O.; Tuzel, Erkan (American Physical Society, 2019-01)

Recent discoveries of gravitational wave (GW) signals from astrophysical compact binary systems of neutron stars and black holes have firmly established them as prime sources for advanced GW detectors. Theoretical templates ...
Design, synthesis and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2

Shah, Chetan P.; Purushothaman, Gayathri; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya; Juvale, Kapil; Kharkar, Prashant S. (Elsevier, 2019-06)

Inosine 5′-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) catalyzes a crucial step in guanine nucleotide biosynthesis, thereby governing cell proliferation. In contrast to mammalian IMPDHs, microbial IMPDHs are relatively ...
Interaction of a dimeric carbocyanine dye aggregate with bovine serum albumin in non-aggregated and aggregated forms

Reddy Patlolla, Prathap; Desai, Nakshi Nayan; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2018-10)

The interaction of fluorescent dyes with serum proteins has garnered significant interest owing to potential for non-covalent labeling and imaging applications. In this work, dimeric benzothiazole-based trimethine cyanine ...
Identification of PfENR inhibitors: a hybrid structure?based approach in conjunction with molecular dynamics simulations

Manhas, Anu; Patel, Anjali; Lone, Mohsin Y.; Jha, Prafulla K.; Jha, Prakash C. (Wiley, 2018-08)

In the current study, we have constructed receptor-based pharmacophore models by exploiting the Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) structural proteome. The derived models were subjected to ...
Carbamylation promotes amyloidogenesis and induces structural changes in Tau-core hexapeptide fibrils

Guru, Krishnakumar Viswanathan; Baweja, Lokesh; Ralhan, Krittika; Gupta, Sharad (Elsevier, 2018-07)

Carbamylation is a non-enzymatic post-translational modification (PTM), which involves the covalent modification of N-terminus of protein or ε-amino group of Lys. The role of carbamylation in several age-related disorders ...
Self-assembled glycosylated chalcone–boronic acid nanodrug exhibits anticancer activity through mitochondrial impairment

Ghosh, Chandramouli; Gupta, Neha; Mallick, Abhik; Santra, Manas Kumar; Basu, Sudipta (ACS Publications, 2018-07)
Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function

Patel, Divyesh; Patel, Manthan; Westermark, Bengt; Singh, Umashankar (BioMed Central, 2018-07)

Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine ...
Qualitative and quantitative analysis of intermolecular interactions in xanthenedione derivatives

Purushothaman, Gayathri; Thiruvenkatam, Vijay (International Union of Crystallography, 2018-07)

The existence of intermolecular interactions and the conformational geometry adopted by molecules are related to biological activity. Xanthenedione molecules are promising and emerging antioxidants and acetylcholinesterase ...
Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils

Haja, Esraa; Loseva, Yelena; Guru, Krishnakumar Viswanathan; Pichinuk, Edward; Engel, Hamutal; Raveh, Avi; Gazit, Ehud; Segal, Daniel (Elsevier, 2018-04)

Background Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. ...
The Neuropsychology of movement and movement disorders: neuroanatomical and cognitive considerations

Haaland, Kathleen Y.; Dum, Richard P.; Mutha, Pratik K.; Strick, Peter L.; Tröster, Alexander I. (Cambridge University Press, 2018-10)

This paper highlights major developments over the past two to three decades in the neuropsychology of movement and its disorders. We focus on studies in healthy individuals and patients, which have identified cognitive ...
High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer

Bhoir, Siddhant; Shaik, Althaf; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya (Nature Publishing Group, 2018-03)

Human Tousled-like kinases (TLKs) are highly conserved serine/threonine protein kinases responsible for cell proliferation, DNA repair, and genome surveillance. Their possible involvement in cancer via efficient DNA repair ...
Dimeric carbocyanine dye and nucleic acid aptamer mediated detection of food borne toxin

Chilka, Pallavi; Pallavi, Patlolla; Reddy, Prathap; Datta, Bhaskar (NISCAIR-CSIR, India, 2018-02)

Food borne toxins represent a serious challenge to the advances in the operation of the food industry with respect to food processing and distribution. While selective identification of the toxins can be easily accomplished ...
Impact of graphene-based nanomaterials (GBNMs) on the structural and functional conformations of hepcidin peptide

Singh, Krishna P.; Baweja, Lokesh; Wolkenhauer, Olaf; Rahman, Qamar; Gupta, Shailendra K. (Springer Verlag, 2018-03)

Graphene-based nanomaterials (GBNMs) are widely used in various industrial and biomedical applications. GBNMs of different compositions, size and shapes are being introduced without thorough toxicity evaluation due to the ...
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

Guru, Krishnakumar Viswanathan; Paul, Ashim; Segal, Daniel (Nature Publishing Group, 2018-01)

Intra-cellular tau protein tangles and extra-cellular ?-amyloid plaques are hallmarks of Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded ?-sheet rich ...
Structural means of assessing the association of hamartin and tuberin

Natarajan, Nalini; Thiruvenkatam, Vijay (International Union of Crystallography, 2017-08)

mTOR pathway is one of the most important and well-studied signalling cascades with respect to cancer. The majorcontrollers of mTOR are the tumour suppressors Hamartin (TSC1) and Tuberin (TSC2), which lies in the heart of ...

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